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However, in our study, it was found that the TID20 values for sulfone and acid metabolites of modafinil are virtually identical suggesting that in low doses, these compounds ought to produce the identical anticonvulsant results. In mice, modafinil administered intraperitoneally at a dose of 300 mg kg−1 protected 100 % of animals towards MES-induced seizures, while sulfone metabolite offered solely a 50 % safety and intermediate acid was toxic at that dose (Chatterjie et al. Based on the aforementioned data, it can be assumed that all of the behavioral assessments carried out on this study (i.e., chimney test, passive avoidance process, and grip energy take a look at) are delicate sufficient to detect any possible acute adversarial effects in animals receiving the combos of modafinil, its metabolites, and GBR12909 with classical AEDs. Contemplating the outcomes from our examine (primarily based on the TID20 values as decided within the MEST test), it is shocking that a previous research reported modafinil administered alone in a dose of 300 mg kg−1 (i.p.) exerts one hundred % safety in opposition to MES-induced seizures, whereas sulfone and acid metabolites of modafinil utilized in the identical dose protects 50 and 0 % of animals in the screening mouse MES test, respectively (Chatterjie et al.